Hyperglycosylation is a metabolic driver of Alzheimer's disease

The article identifies hyperglycosylation—a process where excess glucose leads to abnormal sugar attachments on proteins—as a key metabolic driver of Alzheimer's disease. This mechanism is shown to promote amyloid-beta aggregation, tau pathology, and neuroinflammation. The findings suggest hyperglycosylation could be a therapeutic target for early intervention in Alzheimer's.