Theories of Ageing [pdf]
This article reviews major biological theories of ageing, including evolutionary, molecular, cellular, and systemic perspectives. It discusses mechanisms such as oxidative stress, telomere shortening, and genetic regulation that contribute to the ageing process.
Background
- A 2007 academic review from the journal IUBMB Life surveying major theories of biological aging: evolutionary (mutation accumulation, antagonistic pleiotropy, disposable soma), molecular (telomere shortening, oxidative stress, mitochondrial damage), and systemic (neuroendocrine, immunological).
- It predates many modern developments: senolytic drugs, epigenetic clocks, the longevity biotech industry (Altos Labs, Calico), and the framing of aging as a treatable disease.
- Why it matters: aging is the primary risk factor for most chronic diseases. Which theory is correct shapes where billions in research funding go — antioxidants, telomerase, caloric restriction, or cellular reprogramming.